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Guest Principal Investigator

TIAGO OUTEIRO

About the Lab

Our research interests are focused on the understanding of the molecular mechanisms involved in ageing and age-associated disorders, such as Parkinson’s, Huntington’s, or Alzheimer’s disease. These diseases are intimately associated with protein misfolding and aggregation in specific regions of the brain, a process that is also present in diabetes and cancer.

Because the molecular pathways involved in protein homeostasis are highly conserved, we employ a wide variety of model organisms, from the simple but powerful budding yeast to mammalian cell culture and mice, to study the origin of the problems.

Our ultimate goals are to develop novel therapeutic approaches for these and other related disorders. We work closely together with clinicians in order to accelerate drug discovery efforts, translating basic research into clinical applications that will improve the lives of patients.

For more information please visit: http://www.neurodegeneration.uni-goettingen.de/

Team Members

Selected Publications

2021 | Oliveira LMA, Gasser T, Edwards R, Zweckstetter M, Melki R, Stefanis L, Lashuel HA, Sulzer D, Vekrellis K, Halliday GM, Tomlinson JJ, Schlossmacher M, Jensen PH, Schulze-Hentrich J, Riess O, Hirst WD, El-Agnaf O, Mollenhauer B, Lansbury P, Outeiro TF. Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease. NPJ Parkinsons Dis.. Jul 26;7(1):65. doi: 10.1038/s41531-021-00203-9. PMID: 34312398; PMCID: PMC8313662.

2021 | Flores-León M, Lázaro DF, Shvachiy L, Krisko A, Outeiro TF. In silico analysis of the aggregation propensity of the SARS-CoV-2 proteome: Insight into possible cellular pathologies. Biochim Biophys Acta Proteins Proteom.. Oct;1869(10):140693. doi: 10.1016/j.bbapap.2021.140693. Epub 2021 Jul 5. PMID: 34237472; PMCID: PMC8256665.          

2021 | Dominguez-Meijide A, Parrales V, Vasili E, González-Lizárraga F, König A, Lázaro DF, Lannuzel A, Haik S, Del Bel E, Chehín R, Raisman-Vozari R, Michel PP, Bizat N, Outeiro TF. Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo. Neurobiol Dis.. Apr;151:105256. doi: 10.1016/j.nbd.2021.105256. Epub 2021 Jan 8. PMID: 33429042.

2017 | Ferreira DG, Temido-Ferreira M, Vicente Miranda H, Batalha VL, Coelho JE, Szegö ÉM, Marques-Morgado I, Vaz SH, Rhee JS, Schmitz M, Zerr I, Lopes LV, Outeiro TF. α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B. Nat Neurosci.. Nov;20(11):1569-1579. doi: 10.1038/nn.4648. Epub 2017 Sep 25. PMID: 28945221.

2017 | Vicente Miranda H, Szego ÉM, Oliveira LMA, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Ponces-Freire A, Lashuel HA, Santos NC, Lopes LV, Xiang W, Jovin TM, Penque D, Engelender S, Zweckstetter M, Klucken J, Giorgini F, Quintas A, Outeiro TF. Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies. Brain.. May 1;140(5):1399-1419. doi: 10.1093/brain/awx056. Erratum in: Brain. 2021 Jul 28;144(6):e58. PMID: 28398476.

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Additional Info

TIAGO OUTEIRO
Invited Principal Investigator

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