Several studies, including ours, unravelled that many genes identified in developmental disorders with clinical manifestations in the brain (e.g. primary microcephaly) encode proteins involved in mitotic machinery or functions related to the cell cycle regulation. Despite mitosis being a ubiquitous cellular process, it remains puzzling why the brain is frequently affected. Our lab aims to find new answers to “What makes the brain uniquely vulnerable?”. Here, we aim to understand the reasons that render brain development more susceptible to defects in the mitotic machinery.

Also, age-associated neurodegenerative diseases are associated with aneuploidy. Yet, remains unclear the routes to aneuploidy that underlie these pathologies, including neurodegenerative rare syndromes.

 

More information about the lab here.