Models Used

Cell Lines
IPSCs/Organoids
elegans
Drosophila
Small rodents

Research Focus & Expertise

Ageing
Brain/Neuroscience
Biomarkers

Core Techniques

Tissue culture
Protein biophysics and biochemistry
In vivo work
Flow cytometry
Western blot
Microscopy
Next generation sequencing/transcriptomics
Proteomics
Recombinant DNA techniques
Molecular genetics tools
Electrophysiology

ABOUT THE LAB

Our research interests are focused on the understanding of the molecular mechanisms involved in ageing and age-associated disorders, such as Parkinson’s, Huntington’s, or Alzheimer’s disease. These diseases are intimately associated with protein misfolding and aggregation in specific regions of the brain, a process that is also present in diabetes and cancer.

Because the molecular pathways involved in protein homeostasis are highly conserved, we employ a wide variety of model organisms, from the simple but powerful budding yeast to mammalian cell culture and mice, to study the origin of the problems.

Our ultimate goals are to develop novel therapeutic approaches for these and other related disorders. We work closely together with clinicians in order to accelerate drug discovery efforts, translating basic research into clinical applications that will improve the lives of patients.

For more information please visit: http://www.neurodegeneration.uni-goettingen.de/

Tiago Outeiro

Tiago Outeiro

Investigador Principal

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