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Thyroid hormones in development and ageing Group

MARCO CAMPINHO

About the Lab

Thyroid hormones comprise the prohormone thyroxine (T4) and its metabolite triiodothyronine (T3, hereafter thyroid hormone) that acts as the active hormone. T3 is involved in all life-stages in humans. Altered T3 signalling and homeostasis constitute some of the most prevailing endocrine disorders in humans. The research group in focused in understanding the role of T3 in development and ageing. The research strategy uses the model organism zebrafish together with CRISPR/Cas9 loss of function mutants, coupled to omics and live imaging to gain insight into the functional role of T3 in vertebrate development and ageing.

Three research lines are pursuit:

In deciphering the role of maternal T3 in vertebrate embryogenesis, neurodevelopment and T3-related congenital diseases;
Understand T3 role in post-natal vertebrate development;
Role of T3 in ageing.

Team Members

André Andrade

PhD student

andreandrade@gmail.com

Bld. 8, Lab 2.34

Selected Publications

2019 | Li, Y.-F., Canário, A. V. M., Power, D. M., Campinho, M. A.*. Ioxynil and diethylstilbestrol disrupt vascular and heart development in zebrafish. Environment International. 124, 511-520.

2018 | Campinho, M. A.*, Silva, N., Martins, G. G., Anjos, L., Florindo, C., Roman-Padilla, J., Garcia-Cegarra, A., Louro, B., Manchado, M., Power, D. M. . A thyroid hormone regulated asymmetric responsive centre is correlated with eye migration during flatfish metamorphosis. Scientific Reports. 8, 12267.

2017 | Silva, N., Louro, B., Trindade, M., Power, D. M., Campinho, M. A.*. Transcriptomics reveal an integrative role for maternal thyroid hormones during zebrafish embryogenesis. Scientific Reports. 7, 16657.

2015 | Campinho, M. A.*, Silva, N., Roman-Padilla, J., Ponce, M., Manchado, M., Power, D. M.. Flatfish metamorphosis: A hypothalamic independent process? Molecular and Cellular Endocrinology. 404, 16-25.

2014 | Campinho, M. A.*, Saraiva, J., Florindo, C., Power, D. M. . Maternal thyroid hormones are essential for neural development in zebrafish. Mol Endocrinol. 28, 1136-1144.

Projects

Project: Development of loss-of-function MOB4 CRISPR/Cas9 zebrafish mutant lines, “CromSeg: Molecular mechanisms of chromosome segregation”
Period of execution: 2018-2021
Coordinator: Álvaro Tavares, FMCB
Funding agency: FCT project 30014 FEDER

Project: European Marine Biological Resource Centre Portugal (01/SAICT/2016)
Period of execution: 2018-2020
Coordinator: Adelino Canário
Role: Researcher responsible for the acquisition, installation and management of the Single plain illumination microscopy unit at CCMAR
Funding agency: EU funding

Project: Salt stimulated and aging smolts: do we compromise post-smolt welfare in Norwegian salmon farming?
Period of execution: 2018-2021
Coordinator: Artic University of Norway
Role: Marco Campinho is Co-PI
Funding agency: Norwegian Research Council

Awards

2017 | Public choice prize for the best scientific image at ArtDev exhibition organised by the Portuguese Society for Developmental Biology

2014 | Best oral presentation in the 27th Conference of European Compared Endocrinologist (Rennes, France) with a presentation entitled: “Flatfish metamorphosis: a not so asymmetric tale”

2013 | Honourable mention for the submitted poster entitled “Maternal thyroid hormone role in development of zebrafish spinal cord neurons via MCT8” in the 2nd Meeting of the Portuguese and Spanish Society for Developmental Biology (Lisbon, Portugal)

2012 | 3rd place in the international SVI Huygens Image contest for images in biology (The Netherlands). The award was attributed to a confocal microscopy image of a pre-metamorphic sole larvae head fluorescently labelled to depict bone and muscle.

Funding Agencies

Events to Disseminate

Additional Info

MARCO CAMPINHO

PRINCIPAL INVESTIGATOR

Bld. 8, Lab 2.34

macampinho@ualg.pt