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Temporal Control of Cell Diferenciation Group

RAQUEL P. ANDRADE

About the Lab

HOW DO CELLS COUNT TIME?

Biorhythms underlie many aspects of our lives ensuring that all cellular processes occur in their optimal temporal niche. Molecular oscillators with circadian or ultradian (<24h) rhythms have been independently characterized in multiple organisms/cells and revealed to be crucial timekeeping mechanisms operating during DEVELOPMENT, AGEING AND DISEASE. Our group studies one such oscillator – the EMBRYO MOLECULAR CLOCK (EC) – which regulates the periodic formation of the vertebrate embryo axial skeleton precursors. EC gene expression oscillations are driven by negative feedback mechanisms and its periodicity depends on timely mRNA and protein turnover. We aim to answer the following questions:

  • What regulates the periodicity of the EC?
  • What is the functional role of EC gene expression oscillations?
  • How does the dysregulation of the EC impact tumorigenesis?

Team Members

Isabel Palmeirim
co-Principal Investigator
Rui Silva
Assistant Researcher

Bld. 2, Lab 3.64

Gil Carraco
PhD Student

Bld. 2, Lab 3.64, ext: 220238

Ana Cristina Maia-Fernandes
PhD Student

Bld. 2, Lab 3.64, ext: 220238

Alene Tavares
Master Student

Bld. 2, Lab 3.64

Ana Conceição
Master Student
André Jesus
Master Student

Selected Publications

2021 | Isabel Duarte*, Gil Carraco*, Nayara T. D. de Azevedo, Vladimir Benes, Raquel P. Andrade. gga-miRNOME, A microRNA-sequencing dataset from chick embryonic tissues. Scientific Data (in press)

2021 | Nóbrega A, Maia-Fernandes AC, Andrade RP. Altered Cogs of the Clock: Insights into the Embryonic Etiology of Spondylocostal Dysostosis. J Dev Biol. 9:5.

2020 | *Duarte, Isabel, *Liber, Marta, & Andrade, Raquel P. FrozenChicken: Promoting the meta-analysis of chicken microarray data. (Version1.0). 

2020 | Filipe Pinto, Ângela M. Costa, Raquel P. Andrade, Rui Manuel Reis. Brachyury Is Associated with Glioma Differentiation and Response to Temozolomide. Neurotherapeutics,17:2015–2027

2020 | Filipe Pinto, Ângela Costa, Gisele C de Almeida, Marcus M Matsushita, Sandra Costa, Viviane Silva, Vera Gonçalves, Celeste M Lopes, Carlos Clara, Aline Becker, Luciano Neder, Glaucia Hajj, Isabela Werneck da Cunha, Chris Jones, Raquel P Andrade, Rui M Reis. The T‐box transcription factor brachyury behaves as a tumor suppressor in gliomas. The Journal of Pathology, 251:87-99.

2019 | Ana C Maia-Fernandes, Tomas Pais de Azevedo, Ana Marreiros, Isabel Palmeirim, Raquel P Andrade. The posterior limit of the area pellucida (pPL) as a reliable proxy for the end of the primitive streak in chick elongation studies. Matters (10.19185/matters.201903000031)

2016 | Caroline J. Sheeba, Raquel P. Andrade and Isabel Palmeirim. Mechanisms of vertebrate embryo segmentation: Common themes in trunk and limb development. Semin Cell Dev Biol.  49:125–134.

2015 | Analuce Gouveia1,2, Hugo M. Marcelino1,2, Lisa Gonçalves3,4, Isabel Palmeirim3,4 and Raquel P. Andrade1,2. 2015. Patterning in Time and Space: HoxB Cluster Gene Expression in the Developing Chick Embryo. Cell Cycle 14:135-45. 

2014 | Filipe Pinto1,2, Nelma Pértega-Gomes1,2, Márcia S Pereira1,2, José R Vizcaíno3, Pedro Monteiro4, Rui M Henrique5,6,7, Fátima Baltazar1,2, Raquel P Andrade1,2, Rui M Reis1,2,8. 2014. T-box transcription factor Brachyury is associated with prostate cancer progression and aggressiveness. Clin Cancer Res 20: 1–13.

2014 | Caroline J. Sheeba1,2, Isabel Palmeirim2* and Raquel P. Andrade1*. 2014. Limb patterning: from signalling gradients to molecular oscillations. J Mol Biol 426:780-4. 

2010 | Tatiana P. Resende1, Mónica Ferreira1, Ana Teresa Tavares2,3, Marie-Aimée Teillet4,5, Isabel Palmeirim6* and Raquel P. Andrade1*. 2010. Sonic hedgehog in temporal control of somite formation. Proc Natl Acad Sci U S A. 107:12907-12.

2007 | Caroline J. Sheeba, Isabel Palmeirim and Raquel P. Andrade. Chick Hairy1 protein interacts with Sap18, a component of the SIN3/HDAC transcriptional repressor complex. BMC Developmental Biology 7:83. 

2005 | Andrade, R.P., Pascoal, S., and Palmeirim, I. Thinking clockwise. Brain Res Rev. 49:114-119.

Projects

Awards

Funding Agencies

Events to Disseminate

Additional Info

RAQUEL P. ANDRADE
PRINCIPAL INVESTIGATOR

Bld. 2, Lab 3.64, ext: 7481

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