Models Used

Cell Lines
IPSCs/Organoids

Research Focus & Expertise

Cellular biology in health and disease
Cardiovascular development

Core Techniques

Tissue culture
Protein biophysics and biochemistry
In vivo work
Flow cytometry
Western blot
Microscopy
Next generation sequencing/transcriptomics
Proteomics
Recombinant DNA techniques
Molecular genetics tools
Reprogramming of somatic cells

ABOUT THE LAB

The Stem Cells Biology Laboratory (SCL) investigates mostly the molecular mechanisms involved in pluripotency, heart development and cardiomyopathies using embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC). We are particularly interested in the identification of pathways and genes controlling the establishment and the maintenance of pluripotent stem cells (ESC and iPSC), and we have used these cells to unravel the early mechanisms of cardiovascular differentiation and congenital heart disease. Importantly, we have identified molecules in the ESC’s secretome that can rescue the lethality and heart developmental defects of deficient zebrafish embryos, when supplemented at 1-cell stage. Recently, we have also gained interest in understanding the mechanisms involved in the stemness and biology of cancer stem cells.

José Bragança

José Bragança

Investigador Principal

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